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Deficient EBV-Specific B- and T-Cell Response in Patients with Chronic Fatigue Syndrome

Figure 4

CFS patients show diminished cytokine response against EBV.

Whole blood of healthy controls and CFS patients was analyzed by Multiplex-Immunoassay for (A) IFN-γ production after stimulation with either EBV-lysate (control n = 29, CFS n = 22), EBNA-1 peptide (control n = 24, CFS n = 11) or SEB (control n = 21, CFS n = 11) and (B) after EBV-lysate stimulation for TNF-α (control n = 29, CFS n = 22), IL-2 (control n = 29, CFS n = 22) and IL-10 (control n = 25, CFS n = 13). Statistical analysis was performed using the two-tailed Mann-Whitney-U test with * p<0.05 and *** p<0.001.

Figure 4