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Deficient EBV-Specific B- and T-Cell Response in Patients with Chronic Fatigue Syndrome

Figure 1

EBNA antibody response is reduced in CFS patients.

(A) Serum IgG titers were assessed for healthy controls and CFS patients by ELISA for EBV VCA-IgG (control n = 57, CFS n = 63), (B) EBNA-IgG (control n = 57, CFS n = 63), (C) EBV VCA-IgM (control n = 57, CFS n = 63), (D) CMV-IgG (control n = 32, CFS n = 41) and (E) CMV-IgM (control n = 32, CFS n = 41). Statistical analysis was performed using the two-tailed Mann-Whitney-U test and for EBNA-IgG and EBV VCA-IgM Fisher's exact one-tailed test for association analysis with * p<0.05.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0085387.g001