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Probiotic Microbes Sustain Youthful Serum Testosterone Levels and Testicular Size in Aging Mice

Figure 6

Systemic depletion of IL-17 recapitulates reproductive fitness attributes of L. reuteri.

Compared to sham IgG-treated control mice, 12 month-old mice depleted of IL-17A had a. increased paired testicular weights; b. increased cross-sectional ST areas; c. increased germ cell nuclear volumes; d and e. increased interstitial Leydig cell areas. Hematoxylin and eosin. Bars = 100 µm; f. increased Leydig cell nuclear volumes and total number per testis and g. decreased ST atrophy. *p<0.05, **p<0.001, ***p<0.0001.

Figure 6

doi: https://doi.org/10.1371/journal.pone.0084877.g006