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Probiotic Microbes Sustain Youthful Serum Testosterone Levels and Testicular Size in Aging Mice

Figure 5

Dietary L. reuteri rescues mice from age-associated testicular atrophy.

a. Representative histology of Swiss mouse testes at the age of 12 months. The aged control mouse testes demonstrated atrophic seminiferous tubules. By contrast, L. reuteri-fed mice had uniformly normal ST epithelium with rare atrophic tubules. Hematoxylin and eosin. Bars = 100 µm. The y-axis in the bar graph stands for the mean±SEM of the atrophic/total ST ratio counted in each experimental group;**p<0.001. b. Ki-67-specific immunohistochemistry in the testes of 12-months-old mice. A side-by-side comparison of representative images from control and L. reuteri-fed mouse testes reveals that the probiotic organism counteracts the age-associated decrease of epithelial proliferation observed in control mice. DAB chromogen, Hematoxylin counterstain. Bars = 100 µm.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0084877.g005