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Microbial Symbionts Accelerate Wound Healing via the Neuropeptide Hormone Oxytocin

Figure 8

L. reuteri primes T regulatory cells via an oxytocin-dependent mechanism for enhanced wound healing.

Wild type mice fed L. reuteri in their drinking water exhibit enhanced wound healing over untreated controls. This effect is entirely transferable with Foxp3+ Tregs primed in a mouse host feeding on L. reuteri. In the absence of oxytocin, feeding mice with L. reuteri provides no wound healing benefit, and the CD4+CD25+CD45Rblo Tregs from these animals are unable to convey wound-healing advantages.

Figure 8

doi: https://doi.org/10.1371/journal.pone.0078898.g008