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Microbial Symbionts Accelerate Wound Healing via the Neuropeptide Hormone Oxytocin

Figure 5

Depletion of CD25+ cells abolishes the L. reuteri effect in wound healing while depletion of IL-17 restores the wound healing benefit.

(a) Male and female C57BL/6 mice (n = 8 per group) depleted of CD25+ cells by anti-CD25 antibody have larger wounds when compared with sham isotype IgG-treated control mice, despite uniform L. reuteri consumption in both groups. (b) The wounds of CD25 cell-depleted mice do not show the histopathological evidence of the typical L. reuteri-induced accelerated wound repair process, namely sham IgG exhibit complete epidermal closure and mature granulation tissue filling of the wound gap at 6 days after biopsy. (c) (d) Depletion of IL-17A benefits wound healing closure. Hematoxylin and Eosin (b and d). Scale bars = 250 µm.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0078898.g005