Activation of Notch Signaling Is Required for Cholangiocarcinoma Progression and Is Enhanced by Inactivation of p53 In Vivo
Figure 6
NICD overexpression and loss of p53 is influencing the tumor development of cholangiocarcinomas in mice.
Macro- und microscopic pictures of mice with expression of AlbCre and Notch-ICD and inactivation of p53 at different timepoints like indicated. Each mouse was dissected at the indicated timepoint. H&E staining (20X magnification) was performed and analysis was accordingly done in collaboration with an independent pathologist. Note, there was no tumor either macroscopically or microscopically detected with an age of 3 month. Starting with an age of 6 month, mice with expression of AlbCre, Notch-ICD and loss of p53 developed cholangiocarcinomas.