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Going the Distance for Protein Function Prediction: A New Distance Metric for Protein Interaction Networks

Figure 3

An example of functional annotation with DSD.

The correct functional annotation for GLR1, on the third level of the MIPS hierarchy, 32.01.01 (oxidative stress response) is found among none of its direct neighbors, but with the node that is closest in DSD, MXR2. MXR2 is closest in DSD because it has the most similar neighborhood to GLR1.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0076339.g003