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Pathogenic Intestinal Bacteria Enhance Prostate Cancer Development via Systemic Activation of Immune Cells in Mice

Figure 3

Transfer of mesenteric lymph node (MLN) cells from H hepaticus-infected mice is sufficient to recapitulate prostate cancer in uninfected mice.

Schematic illustration of MLN cells transfer experiments designed to test the hypothesis that local GI tract immune network events cause systematic immune imbalances that determine the fate of preneoplastic lesions in topographically distant epithelia such as those of the prostate gland. Trials used 6 mice per group. Experiments were done in duplicate.

Figure 3