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Ablation of the Id2 Gene Results in Altered Circadian Feeding Behavior, and Sex-Specific Enhancement of Insulin Sensitivity and Elevated Glucose Uptake in Skeletal Muscle and Brown Adipose Tissue

Figure 8

Id2−/− mice display elevated FDG uptake and activated volume of interscapular brown adipose tissue (iBAT).

A) Shows a representative PET acquired image of FDG uptake in sagittal plane highlighting iBAT (dorsal) with high uptake. The injection site (right eye) and bladder are also visible. B) Quantitative analysis of FDG uptake in forelimb skeletal muscle in WT and Id2−/− mice represented as SUV (ANOVA: genotype (G), P = 0.152; sex (S), P<0.05; interaction (I), P = 0.108). C) Micro PET images of FDG uptake in iBAT at transverse (top) and coronal (bottom) planes for WT and mice. D) Quantitative analysis of the iBAT FDG uptake in WT and Id2−/− mice represented as standard uptake value (SUV) (G, P<0.01; S, n.s.; I, n.s.). E) Activated iBAT volumes obtained from micro PET studies of WT and Id2−/− mice (G, P<0.001; S, P<0.001; I, n.s.). F) Activated iBAT volumes of WT mice show a negative correlation with the body mass, which was not observed in the Id2−/− mice. Values shown represent mean ± SEM. *p<0.05 and **p<0.01.

Figure 8

doi: https://doi.org/10.1371/journal.pone.0073064.g008