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Ablation of the Id2 Gene Results in Altered Circadian Feeding Behavior, and Sex-Specific Enhancement of Insulin Sensitivity and Elevated Glucose Uptake in Skeletal Muscle and Brown Adipose Tissue

Figure 3

Resistance to weight gain in Id2−/− mice.

A) Body weight comparison between WT and Id2−/− mice (ANOVA: genotype (G), P<0.05; sex (S), P<0.01; interaction (I), P<0.05). B) Weekly weight gain pattern of Id2−/− and WT mice in cages equipped with a running wheel (G, P<0.01; S, n.s.; I, n.s.). C) Daily food intake of Id2−/− and WT mice in wheel cages (ANOVA: G, P<0.01; S, n.s.; I, n.s). Values shown represent mean ± SEM. *p<0.05, **p<0.01 and ***p<0.001.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0073064.g003