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Ablation of the Id2 Gene Results in Altered Circadian Feeding Behavior, and Sex-Specific Enhancement of Insulin Sensitivity and Elevated Glucose Uptake in Skeletal Muscle and Brown Adipose Tissue

Figure 2

Id2−/− mice show altered daily and circadian patterns of feeding and locomotor activity.

A) Daily feeding activity profile of WT and Id2−/− mice (ANOVA: time (T), P<0.001; genotype (G), n.s.; interaction (I), P<0.01). B) Circadian feeding activity profile of WT and Id2−/− mice (T, P<0.001; G, n.s.; I, P<0.05). C) Daily PIR motion detector general activity profile of WT and Id2−/− mice (T, P<0.001; G, P<0.05; I, P<0.001). D) Circadian general activity profile of WT and Id2−/− mice (T, P<0.001; G, P = 0.15; I, P<0.001). E) Daily wheel running activity profile of WT and Id2−/− mice (T, P<0.001; G, P<0.001; I, P<0.001). F) Circadian wheel running activity profile of WT and Id2−/− mice (T, P<0.001; G, P<0.01; I, P<0.001). The shaded area in the plots represents dark phase of the LD cycle or constant darkness. Values shown represent mean ± SEM. *p<0.05, **p<0.01 and ***p<0.001.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0073064.g002