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Ablation of the Id2 Gene Results in Altered Circadian Feeding Behavior, and Sex-Specific Enhancement of Insulin Sensitivity and Elevated Glucose Uptake in Skeletal Muscle and Brown Adipose Tissue

Figure 1

Id2−/− mice exhibit less locomotor activity compared to WT mice.

A) Daily feeding activity counts of Id2−/− and WT mice (ANOVA: genotype, n.s.; sex, n.s.; interaction, n.s). B) Daily general activity counts in Id2−/− and WT mice determined by passive infrared motion detectors (genotype, P<0.05; sex, P = 0.057; interaction, n.s). C) Daily wheel revolution counts of WT and Id2−/− mice (genotype, P<0.001; sex, P<0.05; interaction, P<0.01). Values represent mean ± SEM. ***p<0.001.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0073064.g001