The Extraction of Simple Relationships in Growth Factor-Specific Multiple-Input and Multiple-Output Systems in Cell-Fate Decisions by Backward Elimination PLS Regression
(A) Input loadings. A wedge indicates the temporal evolution of the indicated molecules from 0 to 360 min (Table 1). (B) Input scores. A wedge indicates the doses of the stimulant. (C) Output loadings. A wedge indicates the temporal evolution (Table 1). (D) Output scores. A wedge indicates the doses of the indicated molecules (Fig. 1). The red and blue colors indicate positive and negative values, respectively (A–D). Scatter plots of input loadings (E), input scores (F), output loadings (G) and output scores (H) of the first and second principal components. The colors correspond to the latent variables (E, G) and stimuli (F, H). The numbers indicate the time (minute for pERK, pCREB, pJNK, pAKT, pp38, c-FOS, c-JUN, EGR1, JUNB and FOSB and hour for neurite lengths, cell viability, cell cycle and cell death).