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The Extraction of Simple Relationships in Growth Factor-Specific Multiple-Input and Multiple-Output Systems in Cell-Fate Decisions by Backward Elimination PLS Regression

Figure 1

The inputs and outputs in the MIMO system for cell-fate decisions in PC12 cells.

The inputs consisted of the 12 time points of pERK, pCREB, pJNK, pAKT, and pp38 in response to 5 doses of 4 stimuli (Tables 1 and S2). The outputs consisted of the 12 time points for protein expression of c-FOS, c-JUN, EGR1, FOSB, and JUNB, and 9 time points for the neurite lengths, cell viability (respiratory chain activity of mitochondria), cell cycle (S-phase fraction) and cell death (Caspase3 activity) in response to 5 doses of 4 stimuli (Tables 1 and S1). The doses of the growth factors are indicated by different colors.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0072780.g001