Oral Administration of Ginseng Ameliorates Cyclosporine-Induced Pancreatic Injury in an Experimental Mouse Model
Figure 1
Effect of KRG on pancreatic function in CsA-induced pancreatic injury.
(A and B) Results of IPGTT among the experimental groups. CsA-treated mice had significantly elevated blood glucose compared with the VH-only control group at 30 and 60 min. CsA plus daily treatment with 0.2 or 0.4 mg/kg KRG (K0.2 or K0.4, respectively) decreased blood glucose levels significantly at 30 and 60 min compared with the CsA-only group. (C) Calculation of the AUCg for the experimental groups. CsA plus K0.2 or K0.4 treatment resulted in a decreased AUCg compared with the CsA-only group. (D) Serum insulin levels in the experimental groups. The CsA plus K0.2 or K0.4 groups had significantly increased insulin levels compared with the CsA-only group. Values are mean ± standard errors (SE: n = 10). #P<0.05 vs. VH; *P<0.05 vs. CsA; †P<0.05 vs. CsA+K0.2; ‡P<0.05 vs. CsA+K0.4.