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Improved Bone Morphogenetic Protein-2 Retention in an Injectable Collagen Matrix Using Bifunctional Peptides

Figure 9

Representative histology image (hematoxylin and eosin stain) from the rat ectopic model obtained at a 2X magnification.

A: 2 µg BMP-2 in 1.5% collagen gel and B: 2 µg BMP-2 with 50-fold molar excess of collagen-BMP-2 bifunctional peptide in 1.5% collagen gel. b – Represent regions of bone; c – represent regions of collagen; cells are stained blue. The image shows only cellular activity in sample A, whereas sample B shows bone formation and increased cellular activity.

Figure 9

doi: https://doi.org/10.1371/journal.pone.0070715.g009