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Improved Bone Morphogenetic Protein-2 Retention in an Injectable Collagen Matrix Using Bifunctional Peptides

Figure 8

Ectopic bone formation with rhBMP-2 delivered in a collagen gel with or without the bifunctional peptide.

rhBMP-2 (2 μg) was delivered in a rat ectopic bone model either alone (no peptide) or in combination with a 50-fold molar excess of the bifunctional peptide (Collagen-BMP peptide). H&E stained slides were scored for osteogenic cellular activity, bone area and bone maturity by two observers and the median score for each group is shown in the figure. ****, p<.0001 vs no peptide.

Figure 8

doi: https://doi.org/10.1371/journal.pone.0070715.g008