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Aureolib — A Proteome Signature Library: Towards an Understanding of Staphylococcus aureus Pathophysiology

Figure 3

Intra-experimental comparison of protein synthesis patterns in response to different stimuli.

Quantification data for all detected protein spots were normalized (total) and standardized (z-score). Significant changes of spot intensities were determined for each experiment (ANOVA, α = 0.1, distribution based on 1000 permutations) and the corresponding expression values were used for hierarchical sample clustering (HCL, Euclidean distance, complete linkage). Accordingly, the stimuli can be divided into two classes: (A) Stimuli causing continuous changes of the protein synthesis pattern and (B) stimuli transiently affecting the protein synthesis pattern.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0070669.g003