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Glycogen Phosphorylase Inhibitor N-(3,5-Dimethyl-Benzoyl)-N’-(β-D-Glucopyranosyl)Urea Improves Glucose Tolerance under Normoglycemic and Diabetic Conditions and Rearranges Hepatic Metabolism

Figure 7

KB228 induced mTORC2 in mice.

Chow-fed (n = 7/7, 6 months of age) and HFD-fed (n = 9/9, 6 months of age) C57/Bl6J male mice underwent vehicle or KB228 treatment (90 mg/kg). 2 hours post-treatment livers were removed and homogenized. From liver homogenates of chow-fed (A) and HFD-fed (B) mice Akt and phospho-Akt (473Ser) levels were determined by Western blotting.

Figure 7

doi: https://doi.org/10.1371/journal.pone.0069420.g007