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Glycogen Phosphorylase Inhibitor N-(3,5-Dimethyl-Benzoyl)-N’-(β-D-Glucopyranosyl)Urea Improves Glucose Tolerance under Normoglycemic and Diabetic Conditions and Rearranges Hepatic Metabolism

Figure 5

Other GPi-s also induce UCP2 expression in HepG2 cells.

(A) Three GPi-s TH, NV50 and NV76 were tested on HepG2 cells. (B–C) HepG2 cells (n = 3) kept under normoglycemic conditions were treated with the inhibitors at the indicated concentrations for 8 hours, then (B) glycogen content and (C) UCP-2 expression was determined as described in Materials and Methods. Error is given as SD throughout the figure. * and *** indicate statistically significant difference between vehicle and GPi-treated groups at p<0.05, or p<0.001, respectively. VEH – vehicle, other abbreviations are in the text.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0069420.g005