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Glycogen Phosphorylase Inhibitor N-(3,5-Dimethyl-Benzoyl)-N’-(β-D-Glucopyranosyl)Urea Improves Glucose Tolerance under Normoglycemic and Diabetic Conditions and Rearranges Hepatic Metabolism

Figure 3

The impact of KB228 on in vivo glucose metabolism.

(A-B) Chow-fed C57/Bl6J male mice (n = 7/7, 6 months of age) underwent vehicle or KB228 treatment, then (A) oxygen consumption and (B) RQ were determined in indirect calorimetry chambers. (C) The same cohorts of mice were subjected to an ipGTT test. (D) Chow-fed C57/Bl6J male mice (n = 4/4, 6 months of age) were subjected to a glucose uptake experiment as described in Materials and Methods. (E-F) HFD-fed C57/Bl6J male mice (n = 9/9, 6 months of age) underwent vehicle, or KB228 treatment, then (E) oxygen consumption and (F) RQ were determined in indirect calorimetry chambers. (G) The same cohorts of mice were subjected to an ipGTT test. * and *** indicate statistically significant difference between vehicle and KB228-treated groups at p<0.05, or p<0.001, respectively.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0069420.g003