N-Acetylcysteine and Allopurinol Confer Synergy in Attenuating Myocardial Ischemia Injury via Restoring HIF-1α/HO-1 Signaling in Diabetic Rats
Figure 4
Effects of NAC and ALP on Cu/Zn superoxide dismutase (Cu/Zn SOD) (A and B), Mn SOD protein expression (D and E) before and after ischemia and reperfusion.
Cardiac GSH/GSSG level before and after cardiac ischemia reperfusion(C and F).Sham, C and D indicate sham operation, control or diabetes respectively. D+NA, D+ NA +SnPP-IX, D+NA+2ME2 indicate diabetic rats treated with NAC+ALP (NA) or NA +SnPP-IX or NA +2ME2, respectively. Data are expressed as means ± S.E.M. (n = 7) *P<0.05 vs. C; # P<0.05 vs. D.