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Microbial Reprogramming Inhibits Western Diet-Associated Obesity

Figure 5

Anti-obesity protection of oral probiotics in outbred Swiss mice requires CD25+ immune cells.

Depletion of CD4+CD25+ Treg cells entirely inhibits probiotic-induced protection from age-associated obesity and abdominal fat pathology (a). Probiotics protect from weight gain unless mice were simultaneously treated with anti-CD25 antibody, in which case animals rapidly became obese. Frequency of prototype crown-like structures was increased in abdominal fat after depletion of CD25+ cells but not in sham IgG-treated control animals (b). Fat histology: Hematoxylin and eosin. Bars = 100 µm.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0068596.g005