Intracellular Water Exchange for Measuring the Dry Mass, Water Mass and Changes in Chemical Composition of Living Cells
a) Single-cell dry density and dry mass distributions of two different human erythrocyte samples. Solid and dashed lines of same color indicate technical replicates. Dashed black line is a 99% bound on the expected dry density of a representative sample if all cells had the median dry density, given known measurement error. inset Population mean values from four patient samples. Error bars are standard deviation of the population. b) Comparison to hemoglobin mass per cell determined with an Advia instrument. Dashed line indicates y = x and solid line is a total least squares fit.