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Adding Diverse Noncanonical Backbones to Rosetta: Enabling Peptidomimetic Design

Figure 1

Chemical structures of noncanonical backbones in Rosetta.

A) Oligooxopiperazines (OOP), B) Peptoids, C) -peptides, D) Hydrogen Bond Surrogate (HBS) helices, E) Oligosaccharides. In A–D, bonds highlighted in red deviate from the traditional peptide backbone. Arrows point to “cut-points” described in text. Brackets delineate a single residue subunit.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0067051.g001