Modes of Action of ADP-Ribosylated Elongation Factor 2 in Inhibiting the Polypeptide Elongation Cycle: A Modeling Study
Figure 2
Statistical reasoning in constructing the temporary stall probability.
(A) Cartoon illustration of arranging 3 stagnant ribosomes (k = 3) within an mRNA ORF containing 7 ribosomes (m = 7). Number of arrangement variations is given at the right column according to the position of the leading stagnant ribosome in the series, j. The formula is summarized as (m–j)!/{(k–1)![(m–j)–(k–1)]!}. (B) Plot of the actual translocating population F versus the translocation-active fraction f. (C) The stall function U(f) [ = F(f)/f] replotted in the normalized form within a physiological range of f