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EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as Tobacco Cigarettes Substitute: A Prospective 12-Month Randomized Control Design Study

Figure 8

Time-course of changes in the frequency of the five most commonly reported adverse events (AEs) from baseline, separately for each study group.

On Y-axis, the number of subjects reporting AEs is depicted. Compared to baseline, a significant reduction in frequency of cough, dry mouth, shortness of breath, and headache was observed at each study visits in all three study groups (per-protocol evaluation, p<0.001, χ2 test). No difference was found in frequency distribution of AEs among study groups (χ2 test).

Figure 8

doi: https://doi.org/10.1371/journal.pone.0066317.g008