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EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as Tobacco Cigarettes Substitute: A Prospective 12-Month Randomized Control Design Study

Figure 5

Time-course of changes in the median exhaled CO levels from baseline, separately for each study group.

A significant reduction (per-protocol evaluation, p<0.0001, Wilcoxon signed-rank test) was observed at each study visits in all three study groups. When significant, between-group differences were indicated (Kruskal-Wallis test). The upper part of the figure illustrates the number of subjects attending each study visit.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0066317.g005