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EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as Tobacco Cigarettes Substitute: A Prospective 12-Month Randomized Control Design Study

Figure 3

Schematic diagram of the ECLAT study design.

Smokers not currently attempting to quit smoking or wishing to do so in the next 30 days were randomized in three study groups: group A (receiving 12 weeks of 7.2 mg nicotine cartridges), group B (receiving 6-weeks of 7.2 mg nicotine cartridges and a further 6 weeks with 5.4 mg nicotine cartridges), and group C (receiving 12 weeks of no-nicotine cartridges). Participants in each group were prospectively reviewed for up to 52-weeks during which smoking habits, eCO levels, adverse events, vital signs, and product preference were assessed at each study visits. Additionally, saliva samples were collected at week-6 and at week-12 (closed triangles) for cotinine measurement in those who stated they had not smoked and with an eCO ≤7 ppm.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0066317.g003