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Alternative Computational Protocols for Supercharging Protein Surfaces for Reversible Unfolding and Retention of Stability

Figure 6

High-charge variant hydrogen bond energy changes per structure (600 total).

In high-charge AvNAPSA designs (AvNAPSA cutoff of 150), removal of hydrogen bonds costs 1.5 to 3 Rosetta energy units per structure (empty bars). In contrast, Rosetta designs with the same net charge preserve hydrogen bonds (solid bars).

Figure 6