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Mechanistic Model of Rothia mucilaginosa Adaptation toward Persistence in the CF Lung, Based on a Genome Reconstructed from Metagenomic Data

Figure 4

Hypothesized adaptions of R. mucilaginosa to the CF lung environment.

The model is based on the comparison between the reference genome DY-18 and the reconstructed genome CF1E. rhs: rearrangement hot spot; Type I R-M: Type I restriction modification; MdaB: Modular of drug activity B; ROS: reactive oxygen species; CRISPR: Clustered Regularly Interspaced Short Palindromic Repeats.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0064285.g004