Ligand Induced Conformational Changes of the Human Serotonin Transporter Revealed by Molecular Dynamics Simulations
Figure 8
Correlation between SASA of the intracellular pathway and the intracellular distance between the scaffold and bundle.
The intracellular scaffold-bundle distance is plotted as a function of the calculated SASA of the intracellular pathway for A) noribogaine, B) serotonin and C) cocaine respectively. In all plots the LeuT crystal structures have been included as reference points; PDB code 2A65 [5] in grey, PDB code 3TT1 [25] as pale red, and PDB code 3TT3 [25] in purple.