Reactive Oxygen Species-Activated Nanoprodrug of Ibuprofen for Targeting Traumatic Brain Injury in Mice
Figure 6
Behavioral testing of memory function using the Barnes Maze.
The Barnes Maze was conducted for five days of training followed by traumatic brain injury (TBI). One day after traumatic brain injury (Day 7 on graph), mice did not demonstrate any significant differences in time to find the escape box. Statistical comparison was performed using a two tailed Student’s t-test, with a level of p = 0.05 considered significant. Day 8 serves as a control in which the location of the box is changed to show that mice are not using other cues such as scent to locate the box.