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Rhesus Macaque Lymph Node PD-1^hiCD4⁺ T Cells Express High Levels of CXCR5 and IL-21 and Display a CCR7^loICOS⁺Bcl6⁺ T-Follicular Helper (Tfh) Cell Phenotype

Figure 2

CD4⁺PD-1^hi T cells are predominantly CCR7^lo, Bcl6⁺, IOCS⁺ and express a central memory phenotype.

Representative dot plots showing the expression of a) Bcl6 and ICOS on CD3⁺CD4⁺ T cells and b) CD28 and CD95 expression on lymph node (LN) PD-1^hi and PD-1^–CD4 T cell subsets. c) Relative proportions of Bcl6⁺, ICOS+, CD28⁺CD95⁺ CD4⁺PD-1^hi T cells in LN. d) Representative histograms and e) Mean fluorescence intensity (MFI) of CCR7 expression on LN PD-1^–, PD-1^int and PD-1^hiCD4 T cell subsets.

doi: https://doi.org/10.1371/journal.pone.0059758.g002