Pioglitazone Improves Cognitive Function via Increasing Insulin Sensitivity and Strengthening Antioxidant Defense System in Fructose-Drinking Insulin Resistance Rats
Figure 3
Effect of pioglitazone on histopathological changes in the hippocampus (a–d) and temporal cortex (e–h) of fructose-drinking insulin resistance rats.
The hippocampal CA1 area (a,b) and temporal cortex (e,f) in the control, and the pioglitazone-treated control groups, rare damaged cells were seen. In the hippocampal CA1 area (c,d) and the temporal cortex (g,h) of the fructose-drinking insulin resistance control and the pioglitazone-treated groups, neurondegeneration was evident, but not difference was found between the two groups. The data were from five independent experiments. Magnification: ×200.