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The Systemic Cytokine Environment Is Permanently Altered in Multiple Myeloma

Figure 3

Patients with multiple myeloma present with a systemic cytokine profile consistent with an anti-inflammatory environment.

Differential expression of cytokines between N2, MGUS, and MM populations (fold change >1.25 with p-values <0.05; exact values for all fold-changes and p-values are in Table 3). MGUS* denotes those cytokines with significant differences in expression between MGUS and MM; MGUS** denotes those cytokines with significant differences in expression between MGUS and N2; (A) pro-inflammatory cytokines (B) anti-inflammatory cytokines, (C) lymphocyte growth factors.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0058504.g003