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Fluorescence-Based High-Throughput Functional Profiling of Ligand-Gated Ion Channels at the Level of Single Cells

Figure 5

Effects of the lindane on α2, α3, α2β and α3β GlyRs as determined by patch-clamp.

A. Examples of currents activated by EC50 glycine concentrations in HEK293 cells expressing the indicated GlyR subunits. Examples of the effects of 100 µM lindane on each GlyR isoform are also shown. B. Mean percentage (± SD) of EC50 glycine current blocked by 100 µM lindane. All results were averaged from 4–7 cells. ***p<0.0001 analysed by unpaired t-test.

Figure 5