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Probiotic Bacteria Induce a ‘Glow of Health’

Figure 5

Dietary supplementation with purified Lactobacillus reuteri in drinking water mimics effects of eating probiotic yogurt on skin histology of aged mice.

Wild type C57BL/6 mice fed purified L. reuteri in drinking water differ significantly from their regular water-fed counterparts by having thicker skin and an increased subcutaneous hair follicle and sebocyte profile. (A) Histomorphometrical analysis reveals significant (P<0.0001) probiotic diet-associated increase in skin thickness and (B) number of subcutaneous hair follicles (P<0.05) in both genders. The y-axis depicts the mean±SEM of histomorphometric counts in each experimental group. (C) In mice treated with L. reuteri in drinking water, the majority of the hair follicles are active (anagen-phase). In contrast, control mice of the same age have predominantly quiescent (telogen-phase) hair follicles. The distribution pattern of hair-follicle staging differs significantly (P<0.0001) among L. reuteri- and control diet-fed in both male and female mice. Numbers on the y-axis of bar graphs represent the mean±SEM of hair follicles classified in each hair cycle stage. (D) Further, adding purified L. reuteri in drinking water lead to a significant (P<0.0001) increase of sebocytes in skin pilosebaceous units. The y-axis stands for the mean±SEM of sebocyte counts per X20 high power field image. Numbers on the y-axis of bar graphs correspond to the mean±SEM of the index of proliferating sebocytes per total number of sebocytes in x40 high power fields.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0053867.g005