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Microfabricated Modular Scale-Down Device for Regenerative Medicine Process Development

Figure 1

Design of the microfabricated culture device.

(a) Exploded view showing all parts of the modular microfabricated culture device. (b) Schematic representation of a longitudinal section of the interconnect assembly, showing compression of the PDMS chip around the inlet/outlet ports (dashed rectangle), by the interconnect. (c) Top view of the microfluidic chip with dashed lines showing the footprints of the lid and interconnect bosses. (d) Cross-sectional view showing the two PDMS layers of the microfluidic chip. The lower ‘spacer’ layer elevates the flow equalisation barriers of the top layer and thus reduces the hydrodynamic shear exposure for the cells.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0052246.g001