Mathematical Modeling of Sustainable Synaptogenesis by Repetitive Stimuli Suggests Signaling Mechanisms In Vivo
Upper Figure: 0–5000 min, Lower Figure: 0–20160 min (14 days) The colored lines show time-course fluctuations of each of the components. Red: G-actin; Green: Stable F-actin; Blue: Dynamic F-actin. External stimuli directly decrease G-actin and increase Dynamic F-actin. Stable F-actin is decreased by the effect of COFILIN. After the third stimulation, the levels of G-actin and Dynamic F-actin change in almost the same manner as before, but Stable F-actin hardly decreases because the COFILIN level is very low and the Drebrin/F-actin cluster stabilizes F-actin at this time and the Drebrin/F-actin cluster increases the Stable F-actin level in a self-feedback manner.