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Mathematical Modeling of Sustainable Synaptogenesis by Repetitive Stimuli Suggests Signaling Mechanisms In Vivo

Figure 9

Example of dynamics of PAK4, LIMK, SSH, COFILIN (interval between stimuli = 720 min).

Red: PAK4; Green: LIMK; Blue: LIMK P; Purple: LIMK PP; Light blue: SSH; Brown: SSH P; Amber: COFILIN; Pink: COFILIN P. PAK4, LIMK, SSH and COFILIN are increased by external stimuli. Immediately after stimuli, LIMK decreases and LIMK PP increases by PAK4 and self-phosphorylation, SSH decreases and SSH P increases by PAK4 and then COFILIN decreases and COFILIN P increases by LIMK PP. Because the generation velocities of SSH and COFILIN are decreased by repetitive stimuli, the COFILIN level becomes very low after the third stimulation.

Figure 9