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Mathematical Modeling of Sustainable Synaptogenesis by Repetitive Stimuli Suggests Signaling Mechanisms In Vivo

Figure 5

Structure of cAMP-PKA module.

This module expresses the activation mechanism of PKA with cAMP. The PKA complex (R2C2) consists of two catalytic units and regulatory (inhibitory) units. External stimuli increase cAMP and four cAMP bind to R2C2. The R2C2-cAMP4 complex releases two catalytic units (PKA-active).

Figure 5

doi: https://doi.org/10.1371/journal.pone.0051000.g005