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Mathematical Modeling of Sustainable Synaptogenesis by Repetitive Stimuli Suggests Signaling Mechanisms In Vivo

Figure 4

Whole view of the model.

The model is written in accordance with Systems Biology Graphical Notation (SBGN) [83]. 0. Black box: External stimulation exists at the most upstream and drives our model. 1. Red box: Hypothetical protein module includes hypothetical proteins which play an important role in possible network succession for long-term synaptic maintenance. 2. Blue box: Actin control module includes actin binding protein: COFILIN and COFILIN kinase/phosphatase. 3. Purple box: Actin dynamics module includes G-actin and F-actin to explain the actin dynamics (polymerization and depolymerization). 4. Orange box: Drebrin module includes the actin binding protein: Drebrin. Drebrin affects actin dynamics and is clustered with F-actin. 5. Green box: Synapse dynamics module includes two kinds of synapses to explain the dynamics of synaptogenesis and synaptic maintenance. The white square boxes linked to two connectors are process nodes, which represent processes that transform one or several entity pools to be identical or different. The circles crossed by a bar linking the upper-right and lower-left corners of an invisible square drawn around the circle () are empty sets which represent the source or sink [84].

Figure 4

doi: https://doi.org/10.1371/journal.pone.0051000.g004