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Diagnostic Peptide Discovery: Prioritization of Pathogen Diagnostic Markers Using Multiple Features

Figure 3

Experimental Distribution of peptide intensities ratios (log2 fold change) vs. statistical significance of the signal (negative log scale of q-value) after multiple testing adjustment.

FDR = False Discovery Rate. The q-value is the FDR analog of the p-value. Panel A corresponds to measurements obtained from a peptide chip assayed with sera from a pool of Chagas positive samples, while panel B corresponds to a chip assayed with sera from healthy donors. Points in the higher-right corner of the quadrant are marked as reactive peptides.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0050748.g003