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Learning from Decoys to Improve the Sensitivity and Specificity of Proteomics Database Search Results

Figure 5

ppm, semi-tryptic and modification searches.

This figure denotes versatility of FlexiFDR on ppm based (plasma data), semi tryptic (QTOF) and Phosphorylation modification searches (Phospho data). Details for searches are given in methods. These different searches depict improved performance after applying FlexiFDR. Panel A shows direct Venn comparisons for the three searches. Their corresponding unique spectra are compared in bar graphs below them in panel B to show the effect.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0050651.g005