Human Anti-Aβ IgGs Target Conformational Epitopes on Synthetic Dimer Assemblies and the AD Brain-Derived Peptide
Figure 3
Plasma inhibition of NAbs binding to Aβ conformers.
The antibody binding curves show Aβ fibril-isolated IVIg IgGs binding to plate-immobilized Aβ fibrils (A) and CAPS (B) in the absence or presence of a 1∶10 dilution of normal human plasma. The plots also show Aβ conformer binding by plasma IgGs alone. The data symbols in Panels A and B represent Aβ conformer binding by antibody preparations as specified in the legend of Panel A.