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Human Anti-Aβ IgGs Target Conformational Epitopes on Synthetic Dimer Assemblies and the AD Brain-Derived Peptide

Figure 3

Plasma inhibition of NAbs binding to Aβ conformers.

The antibody binding curves show Aβ fibril-isolated IVIg IgGs binding to plate-immobilized Aβ fibrils (A) and CAPS (B) in the absence or presence of a 1∶10 dilution of normal human plasma. The plots also show Aβ conformer binding by plasma IgGs alone. The data symbols in Panels A and B represent Aβ conformer binding by antibody preparations as specified in the legend of Panel A.

Figure 3