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Human Anti-Aβ IgGs Target Conformational Epitopes on Synthetic Dimer Assemblies and the AD Brain-Derived Peptide

Figure 2

NAbs binding to Aβ conformers and overlapping peptide fragments.

The antibody binding curves are representative of Aβ fibril-isolated (A) and column flow through (depleted) (B) IVIg fractions against plate-immobilized Aβ conformers and overlapping Aβ peptide fragments, respectively. The data symbols represent antibody binding to the Aβ peptides specified in Panel C. (C) Schematic comparison of Aβ fibril-isolated and flow through IVIg fractions, as well as an anti-Aβ N-terminal mAb, 6E10, binding to the plate-immobilized Aβ conformers and overlapping peptide fragments.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0050317.g002