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Immunization with a Hemagglutinin-Derived Synthetic Peptide Formulated with a CpG-DNA-Liposome Complex Induced Protection against Lethal Influenza Virus Infection in Mice

Figure 1

Location of B cell epitopes used in this study in the HA structure.

(A) Schematic representation of predicted B cell epitopes used in this study. Red, hH5N1 HA58; Green, hH5N1 HA113; Yellow, hH5N1 HA175; Orange, hH5N1 HA233. (B) Location of receptor-binding site. Red, 130-loop; Green, 190-helix; Yellow, 220-loop. (C) Schematic representation of previously reported B cell epitopes. Red, LAH; Green, H5-F10 and CR6261; Yellow, H5-1C9; Cyan, H5-1B12. The image of HA structure of the A/Duck/Singapore/3/1997 strain was created with the use of PyMOL (www.pymol.org) and the HA structure was obtained from the Protein Data Bank (PDB: 1JSM).

Figure 1

doi: https://doi.org/10.1371/journal.pone.0048750.g001