Epigenetic Disruption of the PIWI Pathway in Human Spermatogenic Disorders
Figure 1
DNA methylation microarray analysis determined disease-associated profiles.
(A) Unsupervised hierarchical clustering separated testis with a complete absence of germ cells (SCO) from those with the presence of germ cell lineage, and testis with conserved spermatogenesis (CS) from those with spermatogenic failure (SpF) human samples. (B) Hierarchical clustering of CS, SpF and SCO samples, displaying the 633 CpG sites differentially methylated between CS and SpF samples. (C) Hierarchical clustering of PIWIL1/2 and TDRD1/9 involved in the piRNA processing machinery. Sample number corresponding to that in Table 1 is also indicated.